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© 1989 Oxford University Press

research-article

Supplemental administration of 1{alpha}-hydroxyvitamin D3 inhibits promotion by intrarectal instillation of lithocholic acid in N-methyl-N-nitrosourea-induced colonic tumorigenesis in rats

Akihiko Kawaura 1, Noritoshi Tanida, Kenji Sawada, Makoto Oda and Takashi Shimoyama

Department of Internal Medicine 4, Hyogo College of Medicine 1–1 Mukogawacho, Nishinomiya, Hyogo 663, Japan

1To whom correspondence should be addressed

The effect of 1{alpha}-hydroxyvitamin D3 [1{alpha}(OH)D3) on promotion by intrarectal instillation of lithocholic acid (LC) in N-methyl-N-nitrosourea (MNU)-induced colonic tumorigenesis was studied in a rodent model. Ninety-two female F344 rats received intrarectal injection of 2.5 mg of MNU twice in one week followed by 1 mg of LC or its vehicle alone three times weekly for 48 weeks. Those which received LC were given a concomitant intragastric administration of 0.04 µg of 1{alpha}(OH)D3 or its vehicle alone three times weekly. In the group receiving MNU alone (n=30) five rats bore colomc tumors; in the MNU + LC group (n=32) 15 and in the MNU + LC + 1{alpha}(OH)D3 group (n=30) six rats bore colonic tumors (MNU + LC versus MNU + LC + 1{alpha}(OH)D3 group, P<0.05). These results indicated that promotion of MNU-induced colonic tumorigenesis by LC was suppressed by supplemental administration of 1{alpha}(OH)D3.


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