Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Hasegawa, R.
Right arrow Articles by Takahashi, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hasegawa, R.
Right arrow Articles by Takahashi, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1989 Oxford University Press

research-article

Sequential analysis of quinoline-induced hepatic hemangioendothelioma development in rats

Ryohei Hasegawa 1, Fumio Furukawa, Kazuhiro Toyoda, Hidetaka Sato, Katsumi Imaida and Michihito Takahashi 2

Department of Pathology, National Institute of Hygienic Sciences 1–18–1, Kamiyoga, Setagaya-ku, Tokyo 158, Japan
1Present address: First Department of Pathology, Nagoya City University, Medical School 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan

2To whom correspondence should be addressed

The effect of duration of quinoline treatment on the induction of hepatic hemangioendotheliomas was examined. Groups of male Wistar rats were given 0.25% quinoline in the diet for 4, 8, 12, 16 or 20 weeks and sequentially killed at these time points. Hemangioendotheliomas were only induced in the livers of rats given quinoline for more than 12 weeks and the incidences of small foci of dysplastic endothelial cells and tumors at week 20 did not differ between the 12-, 16- and 20-week-treated groups. Quantitative analysis of the liver sections at week 20 revealed increased relative area occupied by sinusoidal space even after only 4-week exposures. Parenchymal hyperplastic nodules were observed only in one rat each of the 16- and 20-week-treated groups. The present study indicates that dysplastic endothelial foci may develop into hemangioendotheliomas irrespective of whether the carcinogenic stimulus is continued.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.