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© 1989 Oxford University Press

other

The prevention of nitrosomethylurea-induced mammary tumors by d-limonene and orange oil

Terese H. Maltzman 1 2, Lind M. Hurt 1, Charles E. Elson 2, Martin A. Tanner 1 and Michal N. Gould 1 3

1Departments of Human Oncology, University of Wisconsin-Madison 600 Highland Avenue, Madison, WI 53792. USA
2Departments of Nutritional Sciences, University of Wisconsin-Madison 600 Highland Avenue, Madison, WI 53792. USA

3To whom reprint requests should be sent

The monocyclic monoterpenoid d-limonene and its source, orange oil, were found to prevent rat mammary carcinomas induced by the direct-acting carcinogen nitrosomethylurea. This chemopreventive effect was limited to the promotion/progression stage in this carcinogenesis model.


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