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© 1989 Oxford University Press

research-article

Structure of a mutagen from roasted seeds of Moringa oleifera

Irene M. Villasenor 1, Paul Finch 2, Clara Y. Lim-Sylianco 1 and Fabian Dayrit 3

1Institute of Chemistry, University of the Philippines Diliman, Quezon City, Philippines 101
2Department of Chemistry, Royal Holoway and Bedford New College, University of London Egham, Surrey, UK
3Department of Chemistry, Atenco de Manila University Loyola Heights, Quezon City, Philippines

A mutagenic compound was isolated from roasted seeds of Moringa oleifera Lam. Its structure has been elucidated by spectral analysis as 4({alpha}-L-rhamnosyloxy)phenylacetonitrile. The results of the Micronucleus Test, an in vivo method, showed that the number of micronucleated polychromatic erythrocytes (PCE)/1000 PCE for this compound is higher than that of the solvent control, dimethylsulfoxide, and approximates that of the positive control, tetracycline. This indicates that 4({alpha}-L-rhamnosyloxy)phenylacetonitrile is a genotoxic compound.


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