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© 1989 Oxford University Press

research-article

Altered formation of DNA replication intermediates in human 46 BR fibroblast cells hypersensitive to 3-aminobenzamide

Ulf Lönn 1 2, Sigrid Lönn 1 2, Urban Nylen 1 and Gerard Winblad 1

1Radiumhemmet, Karolinska Hospital S-104 01 Stockholm, Sweden
2Department of Histology, Karolinska Institutet S-104 01 Stockholm, Sweden

The appearance of DNA replication intermediates was investigated in a human fibroblast strain (46 BR) which is hypersensitive to the lethal effects of 3-aminobenzamide. 3-Aminobenzamide is an inhibitor of poly(ADP-ribose) synthetase and modulates DNA ligase activity. We detected the same intermediates (10 kb DNA and Okazaki-fragments) as in normal fibroblasts, but kinetics and amounts of intermediates were altered, either as a result of, or in order to overcome the defect in the cells.


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