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© 1989 Oxford University Press
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Comparative dose-response study on the pulmonary carcinogenicity of 1, 6-dinitropyrene and benzo[a]pyrene in F344 rats
Second Department of Pathology, School of Medicine, The University of Tokushima Kuramoto-cho 3–18–15, Tokushima 770
2Department of acteriology, School of Medicine, The University of Tokushima
3Department of Public Health, School of Medicine, Gunma University Showa-machi, Macbashi 371, Japanc
1To whom reprint requests should be sent
The dose dependencies of the lung carcinogenicity of 1, 6-dinitropyrene (1, 6-DNP) and benzo[a]pyrene (BaP) were examined by direct injections of these compounds into rat lungs. A total of 276 male F344 rats were divided into 10 groups and given various doses of 1, 6-DNP or BaP, or no drug (control group). Both chemicals were injected into the lung, as suspensions in beeswax-tricaprylin and the animals were then observed for 104 weeks. The incidences of lung cancer were 0/39 (0%), 4/30 (13%), 13/31 (42%), 22/26 (85%) and 6/9 (67%) in groups treated with 0.003, 0.01, 0.03, 0.1 and 0.15 mg of 1, 6-DNP respectively, and 1/29 (3%), 7/30 (23%) 22/29 (76%) and 9/13 (69%) in those treated with 0.03, 0.1, 0.3 and 1.0 mg of BaP respectively. No lung cancer was found in control rats. Thus the incidences of lung cancer induced by 1, 6-DNP and BaP showed significant dose dependence. At equal doses, the incidence of lung cancer was much higher with 1, 6-DNP than with BaP, and the induction of cancer by 1, 6-DNP was higher even at one-third the dose of BaP. Histologically, most tumours induced by 1, 6-DNP were undifferentiated neoplasms, whereas most of those induced by BaP were well-differentiated squamous cell carcinomas.
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