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© 1990 Oxford University Press

other

Analysis of 1,3-butadiene and other selected gas-phase components in cigarette mainstream and sidestream smoke by gas chromatography-mass selective detection

Klaus D. Brunnemann, Mark R. Kagan, Jonathan E. Cox and Dietrich Hoffmann

Naylor Dana Institute for Diesease Prevention, American Health Foundation Valhalla, NY 10595, USA

An analytical procedure was developed for the analysis of 1,3-butadiene, acrolein, isoprene, benzene and toluene in the gas phase of cigarette smoke and environmental tobacco smoke (ETS) utilizing cryogenic gas chromatography-mass selective detection (GC-MSD). The MSD was operated in the selective ion monitoring (SIM) mode. The compounds of interest eluted in < 15 min. The gas phase of freshly generated mainstream smoke was introduced into the GC - MSD via a 10-port gas sampling valve on a puff-by-puff basis. This method minimizes the ageing of tobacco smoke. The levels of 1,3-butadiene in the mainstream smoke ranged from 16 to 75 µg/cigarette. The gas phase of sidestream smoke was trapped in methanol using three midget impingers at -78°C. The amount of 1,3-butadiene in the sidestream smoke ranged from 205-361 µg/cigarette. The concentration of 1,3-butadiene in ETS in a smoke-filled bar amounted to 2.7-4.5 µg/m3.


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