Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Camus, A.-M.
Right arrow Articles by Bartsch, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Camus, A.-M.
Right arrow Articles by Bartsch, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1990 Oxford University Press

other

Effects of a high fat diet on liver DNA methylation in rats exposed to N-nitrosodimethylamine

A.-M. Camus, J.-C. Béréziat, D.E.G. Shuker, E. Hietanen, C.P. Wild, R. Montesano and H. Bartsch 1

International Agency for Research on Cancer 150 cours Albert-Thomas, F-69372 Lyon Cedex 08, France

1To whom correspondence should be addressed

Previous experiments have shown that a high fat diet changes incidence and tumour sites by N-nitroso-dialkylamines. The purpose of this study was to examine the effect of high and low fat diet on DNA methylation 6 weeks after the end of a chronic N-nitrosodimethylamine (NDMA) exposure (total dose 150 mg/kg). The concentration of O6-methvledeoxyguanosine (O6-MedG) persisted 6 weeks after the last dose of NDMA and was 6- fold higher (P <0.05) in animals on high fat as compared to low fat diet. In another experiment, in which rats on a low and high fat diet received a single NDMA dose (2 mg/kg), the time-dependent removal O6-MedG form liver and the hepatic O6-methylguanine DNA-alkyltransferase activity was not modified by the type of diet. These results indicate that a high fat diet enhances DNA methylation in the liver, after chronic treatment by NDMA, and that this effect is likely to be responsible for an increased incidence of liver haemangiosarcomas.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M. Y. Hong, J. R. Lupton, J. S. Morris, N. Wang, R. J. Carroll, L. A. Davidson, R. H. Elder, and R. S. Chapkin
Dietary Fish Oil Reduces O6-Methylguanine DNA Adduct Levels in Rat Colon in Part by Increasing Apoptosis during Tumor Initiation
Cancer Epidemiol. Biomarkers Prev., August 1, 2000; 9(8): 819 - 826.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.