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© 1990 Oxford University Press

other

Chemical-retroviral cooperative carcinogenesis and its molecular basis in NIH/3T3 cells

Yehudith Hassan, Esther Priel, Shraga Segal, Mahmoud Huleihel and Mordechai Aboud 1

Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev Beer Sheva, Israel

1To whom correspondence should be addressed

We demonstrate in this study that infection with Moloney murine leukemia virus (M-MLV) and exposure to 3-methyl-cholanthrene (3-MC) can cooperate to transform NIH/3T3 mouse fibroblasts. M-MLV seems to stimulate the expression of c-myc and of a certain major histocompatibility complex (MHC) class I gene. Yet M-MLV infection by itself is insufficient to transform these cells. However, exposure of the ingected cells to 3-MC resulted in a rapid cell transformation with concomitant enhancement of c-Ha-ras and H-2K class I MHC gene expression in the transformed cells. No such transformation was observed when uninfected NIH/ 3T3 cells were similarly treated with this carcinogen Colnes of cells transformed by this combined effect of M-MLV and 3-MC were found to be highly tumorigenic in fully immunocompetent allogeneic BALB/c mice. We provide evidence to suggest that the enhanced expression of the H-2K gene in these transformed cells plays an important role in overcoming the BALB/c allogeneic barrier and allowing tumor growth in these mice.


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