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© 1990 Oxford University Press

other

Evidence that weak promotion of carcinogen-initiated cells prevents their progression to malignancy

A. Lakshma Reddy and Philip J. Fialkow

Division of Medical Genetics (RG-25), Department of Medicine, University of Washington Seattle, WA 98195, USA

Repeated promotion of 7,12-dimethylbenz[{alpha}]anthraceneinitiated cells in mouse skin with 12-O-tetradecnoylphorbol-13-acetate (TPA) induces them to grow as premalignat skin papillomas and some of these subsequently progress to carcinomas. In this study, we demonstrate that this TPA-induced progression of initiated cells to papillomas and carcinomas could be prevented by exposing them previously to weak promoting regimens or to agents that mimic TPA activity.


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