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© 1990 Oxford University Press

other

Spontaneous basophilic foci of hepatocellular alteration in Fischer 344 female rats do not exclude iron

K.A. Stitzel, P.A. Horn and M.F. Ezra

The Procter & Gamble Company PO Box 398707, Cincinnati, OH 45239-8707, USA

Iron exclusion has been used to identify foci of hepatocelular alteration (FHA) in rats exposed to known carcinogens. This study investigates whether basophilic FHA occurring spontaneously in aged female Fischer 344 rats also exclude iron. Female rats 514–544 days of age were given supplemental iron by injection for 2 weeks prior to being killed. Serial sections of the liver stained with hematoxylin and eosin or Gomori's stain were examined. Seventy-five basophilic FHA were identifiled; none excluded iron. It may be possible to differentiate spontaneous basophilic FHA from carcinogeninduced, iron-excluding FHA by the use of this staininig method.


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