Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (34)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Autrup, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Autrup, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1990 Oxford University Press

other

Carcinogen metabolism in cultured human tissues and cells

Herman Autrup

Laboratory of Enviromental Carcinogenesis, Fibiger Institute Danish Cancer Society, Ndr. Frihavnsgade 70, DK-2 100 Copenhagen {varphi}, Denmark

A large number of chemical carcinogens require metabolic activation before they are biologically active. The metabolism of a few of these compounds has been investigated in cultured human tissues and cells and the metabolism has been compared with the metabolism in organs from experimental animals in which the compounds induce cancer. Generally, only quantitative differences could be observed between animal and human tissues. The development of new methods to detect carcinogen–DNA adduds makes It feasible to study and compare the metabolism in human and animal tissues of an increasing number of potential human carcinogens. Furthermore, construction of cell lines, expressing the human forms of the carcinogen metabolizing enzymes, by biotechnology pro' a new model to study the metabolism and to monitor for genetic markers in the same cells.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
J. Hukkanen, T. Vaisanen, A. Lassila, R. Piipari, S. Anttila, O. Pelkonen, H. Raunio, and J. Hakkola
Regulation of CYP3A5 by Glucocorticoids and Cigarette Smoke in Human Lung-Derived Cells
J. Pharmacol. Exp. Ther., February 1, 2003; 304(2): 745 - 752.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. Hukkanen, A. Lassila, K. Päivärinta, S. Valanne, S. Sarpo, J. Hakkola, O. Pelkonen, and H. Raunio
Induction and Regulation of Xenobiotic-Metabolizing Cytochrome P450s in the Human A549 Lung Adenocarcinoma Cell Line
Am. J. Respir. Cell Mol. Biol., March 1, 2000; 22(3): 360 - 366.
[Abstract] [Full Text]

Home page
 CarcinogenesisHome page
M. d. M. von Pressentin, W. Kosinska, and J. B. Guttenplan
Mutagenesis induced by oral carcinogens in lacZ mouse (MutaTMMouse) tongue and other oral tissues
Carcinogenesis, November 1, 1999; 20(11): 2167 - 2170.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.