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© 1990 Oxford University Press

other

Spontaneous induction of malignancy in mouse cells by a human small cell lung cancer implanted in nude mice

Vicram Gupata, Srinivasan Rajaraman 1 and Richard Eberle 2

Division of Medical Oncology, Pittsburgh Cancer Institute Pittsburgh, PA
1Department of Pathology, The University of Texas Medical Branch Galveston, TX, USA
2Department of Radiation Therapy, The University of Texas Medical Branch Galveston, TX, USA

This report provides evidence for spontaneous transfer of human tumor DNA in vivo to mouse cells by a human small cell lung cancer nnplanted In nude mice. The transformation of the mouse cells was characterized by the presence of neuro secretory granules, which are hallmarks of small cell lung cancer. The carcinogenicity of the human xenografted tumor DNA was confirmed by transfecting NIH3T3 cells in vivo, suggesting that the human tumor DNA may have been the cause of the transformation of the mouse cells in vivo. The spontaneous induction of malignancy in mouse cells in vivo by human tumor DNA may be a factor of potential import ance in tumor cell heterogeneity and propagation of the malignant state for some tumors. The observations support the thesis that some human cancer cells can transform normal cells to become malignant in vivo.


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