© 1990 Oxford University Press
other |
Induction of the heme oxygenase gene in human skin fibroblasts by hydrogen peroxide and UVA (365 nm) radiation: evidence for the involvement of the hydroxyl radical
Swiss Institute for Experimental Cancer Research Epalinges CH-1066, Switzerland
1Present address: ICRF Clare Hall Laboratories, Blanche Lane, South Mimms, Porters Bar, Herts EN6 3LD. UK
The induction of heme oxygenase by both hydrogen peroxide and UVA (365 nm) radiation in normal human skin flbro blasts is prevented by prior treatment of cells with the specific iron chelators, o-phenanthroline or desferrioxamine. In addition, both iron chelators protected cells against the lethal effects of H treatment or UVA irradiation. We propose that the generation of the highly reactive hydroxyl radical by an iron catalyzed Fenton reaction is involved both in the induction of this stress response and, at least in part, in cell killing by the two treatments. These results are also consistent with the idea that the heme oxygenase gene is induced in response to oxidative stress and that its induction may constitute an inducible protective mechanism against oxidative damage induced by both hydrogen peroxide and UVA radiation.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Q. Lin, S. Weis, G. Yang, Y.-H. Weng, R. Helston, K. Rish, A. Smith, J. Bordner, T. Polte, F. Gaunitz, et al. Heme Oxygenase-1 Protein Localizes to the Nucleus and Activates Transcription Factors Important in Oxidative Stress J. Biol. Chem., July 13, 2007; 282(28): 20621 - 20633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Peng, L. Peng, F. F. Stevenson, S. R. Doctrow, and J. K. Andersen Iron and Paraquat as Synergistic Environmental Risk Factors in Sporadic Parkinson's Disease Accelerate Age-Related Neurodegeneration J. Neurosci., June 27, 2007; 27(26): 6914 - 6922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Ryter, J. Alam, and A. M. K. Choi Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications Physiol Rev, April 1, 2006; 86(2): 583 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Ryter, M. Si, C.-C. Lai, and C.-Y. Su Regulation of endothelial heme oxygenase activity during hypoxia is dependent on chelatable iron Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2889 - H2897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. G. Matz, J.-C. Copin, P. H. Chan, and R. L. Macdonald Cell Death After Exposure to Subarachnoid Hemolysate Correlates Inversely With Expression of CuZn-Superoxide Dismutase Editorial Comment Stroke, October 1, 2000; 31(10): 2450 - 2459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Xi, R. F. Keep, Y. Hua, J. Xiang, J. T. Hoff, and R. L. Macdonald Attenuation of Thrombin-Induced Brain Edema by Cerebral Thrombin Preconditioning • Editorial Comment Stroke, June 1, 1999; 30(6): 1247 - 1255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Terry, J. A. Clikeman, J. R. Hoidal, and K. S. Callahan TNF-alpha and IL-1alpha induce heme oxygenase-1 via protein kinase C, Ca2+, and phospholipase A2 in endothelial cells Am J Physiol Heart Circ Physiol, May 1, 1999; 276(5): H1493 - H1501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Foresti, J. E. Clark, C. J. Green, and R. Motterlini Thiol Compounds Interact with Nitric Oxide in Regulating Heme Oxygenase-1 Induction in Endothelial Cells. INVOLVEMENT OF SUPEROXIDE AND PEROXYNITRITE ANIONS J. Biol. Chem., July 18, 1997; 272(29): 18411 - 18417. [Abstract] [Full Text] [PDF]
|
|