Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Golding, B. T.
Right arrow Articles by Watson, W. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Golding, B. T.
Right arrow Articles by Watson, W. P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1990 Oxford University Press

other

Structure determination of adducts from the reaction of (R)-glycidaldehyde and guanosine

Bernard T. Golding, Gordon Kennedy and William P. Watson 1

Department of Chemistiy, Bedson Building, The University Newcastle upon Tyne NEI 7RU
1Shell Research Ltd, Sittingbourne Research Centre Sittingbourne, Kent ME9 8AG, UK

The structures of the initial adducts formed In the reactions of guanosine or deoxyguanosine with (R)-glycidaldehyde have been determined and compared with those obtained from racemic glycidaldehyde. A new stable adduct has also been identified which is a potential biomarker for glycidaldehyde interactions with DNA. Mechanisms are proposed to account for the formation of all the observed products. The results provide information on the molecular basis for the geno toxicity of glycidaldehyde and compounds which generate this reactive aldehyde in vivo.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.