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© 1990 Oxford University Press

other

Formation of a nitro derivative of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline by photo-irradiation

Misako Hirose 1, Keiji Wakabayashi 1, Spiros Grivas 1 4, Silvio De Flora 2, Nobuhiko Arakawa 3, Minako Nagao 1 and Takashi Sugimura 1

1Carcinogenesis Division, National Cancer Center Research Institute 1–1,Tsukiji 5-chome, Chuo-ku, Tokyo 104, Japan
2Insitute of Hygiene and Preventive Medicine, Umversity of Genoa via Pastore, 1, 16132 Genoa, Italy
3Department of Food and Nutrition, Ochanomizu University 1–1, Otsukn 2-chose, Bunkyo-ku, Tokyo 112. Japan

4Present address: Department of Chemistry, Swedish University of Agricultural Science, PO Box 7015, S-750 07 Uppsala, Sweden

A direct-acting mutagen to Salmonella typhimurium TA98 was found to be formed by exposing 2-amino-3,4-dlmethylimidazo- [4,5-f]quinoline (MeIQ) in acetone to sunlight for 60 min. The direct-acting mutagen in the irradiated sample was purified by HPLC and identified as 3,4-dimethyl-2-nitrolmidazo- [4,5-f]quinoline (NO2-MeIQ). The yield of NO2-MeIQ from MeIQ was estimated to be 0.3%.


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