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© 1990 Oxford University Press

research-article

Studies on the anti-tumor-promoting activity of naturally occurring substances. IV. Pd-II [(+)anomalin, (+)praeruptorin B], a seselin-type coumarin, inhibits the promotion of skin tumor formation by 12-O-tetradecanoylphorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated mice

Hoyoku Nishino, Toro Okuyama 1, Mitsumasa Takata 1, Shoji Shibata 2, Harukuni Tokuda, Junko Takayasu, Teiko Hasegawa, Atsuko Nishino, Hisao Ueyama 3 and Akio Iwashima

Department of Biochemistry, Kyoto Prefectural University of Medicine Kawaramachi-Hirokoji, Kamigyoku, Kyoto 602
1Meiji College of Pharmacy Nozawa, Setagayaku, Tokyo 154
2Laboratory of Natural Medicinal Materials, Minophagen Pharmaceutical Co. Yotsuya, Shinjukuku, Tokyo 160
3Shiga University of Medical Sciences Sets, Ohtsu, Shiga 502-21, Japan

Since Pd-II [(+)anomalin, (+)praeruptorin B], a seselin-type coumarin, was found to inhibit tumor promoter induced phemonenon in vitro, the effect of Pd-II on the in vivo tumorpromoting action of 12-O-tetradecanoylphorbol-13-acetate (IPA) in 7,12-dimethylbenz[a]anthracene-initiated mouse skin was investigated. Pd-II, applied 40 min before the TPA treatment, at a dose of 10 µmol/painting, completely suppressed tumor formation up to 20 weeks of tumor promotion, without any toxicity. Besides Pd-II, various antitumor-promoter coumarins were found in the traditional Chinese medicine Qian-Hu, from which Pd-II was obtained. These coumarins may be useful for the development of an effective method to prevent cancer.


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