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© 1990 Oxford University Press

research-article

Sex and organ differences in oxidative DNA and RNA damage due to treatment of Sprague-Dawley rats with acetoxime or 2-nitropropane

Nie Guo, C.Clifford Conaway, Nalband S. Hussain and Emerich S. Fiala 1

American Health Foundation Valhalla, NY. 10595, USA

1To whom correspondence should be addressed

The hepatocarcinogens 2-nitropropane and acetoxime have previously been found to induce a specific and qualitatively identical pattern of base damage in rat liver DNA and RNA, including the induction of increased levels of 8-hydroxy-guanine.Because both 2-nitropropane and acetoxime are weaker carcinogens in female rats than male rats, we examined the ability ofthese chemicals to induce this pattern of damage in liver and kidney nucleic adds of male and female Sprague-Dawley rats 6and 18 h after administration. Significantly lower levels of 8-hydroxydeoxyguanosine, 8-hydroxyguanoslne and other presumed modified nudeosides discernible by high-performance liquid chromatography with electrochemical detection were found in liver nucleic acids of female rats at both time points. In addition, minimal alteration of nucleic acids was observed in the kidney, which is not a target organ for the carcinogenicity of either 2-nitropropane (2-NP) or acetoxime (ACO). These results support the hypothesis that the specific DNA alterations observed are relevant to the hepatocarcinogenicity of 2-NP and ACO.


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