© 1991 Oxford University Press
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Carcinogenic properties of pharmaceutical agents evaluated in the IARC Monographs programme
International Agency for Research on Cancer 150 cours Albert Thomas, F-69372 Lyon Cedex 08, France
1Department of Pharmacology, Medical School, University of Ioannina GR 45110 Ioannina, Greece
Almost 200 pharmaceutical chemicals and groups of drugs have been evaluated for their carcinogenic properties by working groups convened by the International Agency for the Research on Cancer. Therapeutic agents are exceptional environmental carcinogens In that humans are exposed to relatively pure substances at well-defined dosages. Of those evaluated, 20 are conclusively carcinogenic to humans and 52 are probably or possibly carcinogenic. The human tissues most often affected are bone marrow, skin, urinary bladder, liver, lymphatic tissue and endometrium. In cases In which there is sufficient evidence for carcinogenicity from both epidemiological and experimental studies, the similarity between humans and animals with regard to the target organs involved is close (85%). Since data op carcinogenicity exist for several groups of pharmaceuticals, risk versus benefit evaluations should be made carefully in relation to possible clinical applications.
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