© 1991 Oxford University Press
research-article |
Modifying effects of the naturally occurring antioxidants 
-oryzanol, phytic acid, tannic acid and n-tritriacontane-16,18-dione in a rat wide-spectrum organ carcinogenesis model
First Department of Pathology, Nagoya City University Medical School 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan
The modifying effects of the naturally occurring antioxidants 
-oryzanol, phytic acid, tannic acid and n-tritriacontane-16, 18-dione (TTAD) were investigated in a rat wide-spectnim organ carcinogenesis model. Animals were initiated with two i.p. injections of 1000 mg/kg body wt 2,2'-dihydroxy-di-n-propylnitrosamine (DHPN) followed by two i.g. administrations of 1500 mg/kg body wt N-ethyl-N-hydroxyethylnitrosamine (EHEN), and then three s.c. injections of 75 mg/kg body wt 3,2'-dimethyl-4-amlnobiphenyl (DMAB) during the first 3 weeks. Starting 1 week after the last injection, groups of rats received diet containing 1% -oryzanol, 2% phytic acid, 0.2% TTAD or 1% tannic acid or basal diet alone for 32 weeks. Animals were then killed and complete autopsy was performed at the end of week 36. Histological examination revealed enhancement of lung carcinogenesis by -oryzanol, and the incidence of urinary bladder papillomas to be increased by phytic acid. On the other hand, TTAD inhibited hepatic and pancreatic carcinogenesis. Phytic acid and tannic acid were marginally effective in inhibiting hepatic and colon carcinogenesis respectively. The results thus indicated that naturally occurring antioxidants each exert specific modifying effects depending on the organ site and indicate that wide-spectrum carcinogenesis models are useful for defining complex influences.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Amended Final Report on the Safety Assessment of Oryza Sativa (Rice) Bran Oil, Oryza Sativa (Rice) Germ Oil, Rice Bran Acid, Oryza Sativa (Rice) Bran Wax, Hydrogenated Rice Bran Wax, Oryza Sativa (Rice) Bran Extract, Oryza Sativa (Rice) Extract, Oryza Sativa (Rice) Germ Powder, Oryza Sativa (Rice) Starch, Oryza Sativa (Rice) Bran, Hydrolyzed Rice Bran Extract Hydrolyzed Rice Bran Protein, Hydrolyzed Rice Extract, and Hydrolyzed Rice Protein International Journal of Toxicology, March 1, 2006; 25(2_suppl): 91 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kitamura, A. Nishikawa, H. Nakamura, F. Furukawa, T. Imazawa, T. Umemura, K. Uchida, and M. Hirose Effects of N-Acetylcysteine, Quercetin, and Phytic Acid on Spontaneous Hepatic and Renal Lesions in LEC Rats Toxicol Pathol, August 1, 2005; 33(5): 584 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Orita, M. Hirose, S. Takahashi, K. Imaida, N. Ito, K. Shudo, H. Ohigashi, A. Murakami, and T. Shirai Modifying Effects of 1'-Acetoxychavicol Acetate (ACA) and the Novel Synthetic Retinoids Re-80, Am-580 and Am-55P in a Two-Stage Carcinogenesis Model in Female Rats Toxicol Pathol, February 1, 2004; 32(2): 250 - 257. [Abstract] [PDF]
|
|
|
|
 |
|
 I. Vucenik and A. M. Shamsuddin Cancer Inhibition by Inositol Hexaphosphate (IP6) and Inositol: From Laboratory to Clinic J. Nutr., November 1, 2003; 133(11): 3778S - 3784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ferry, M. Matsuda, H. Yoshida, and M. Hirata Inositol hexakisphosphate blocks tumor cell growth by activating apoptotic machinery as well as by inhibiting the Akt/NF{kappa}B-mediated cell survival pathway Carcinogenesis, December 1, 2002; 23(12): 2031 - 2041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zi, R. P. Singh, and R. Agarwal Impairment of erbB1 receptor and fluid-phase endocytosis and associated mitogenic signaling by inositol hexaphosphate in human prostate carcinoma DU145 cells Carcinogenesis, December 1, 2000; 21(12): 2225 - 2235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N Sharma, P Trikha, M Athar, and S Raisuddin Inhibitory effect of Emblica officinals on the in vivo clastogenicity of benzo alpyrene and acyclophosphamide in mice Human and Experimental Toxicology, June 1, 2000; 19(6): 377 - 384. [Abstract] [PDF]
|
|
|
|
|
|
G. Rimbach and J. Pallauf Phytic Acid Inhibits Free Radical Formation In Vitro but Does Not Affect Liver Oxidant or Antioxidant Status in Growing Rats J. Nutr., November 1, 1998; 128(11): 1950 - 1955. [Abstract] [Full Text]
|
|