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© 1991 Oxford University Press

research-article

Tumours of mesothelial origin in rats following inoculation with biogenic sifica fibres

Tarlochan S. Bhatt, Stephen Lang 1 3 and Mary N. Sheppard 2

Joint Academic Unit of Obstetrics, Gynaecology and Reproductive Physiology, The Royal London Hospital Whitechapel, London E1 1BB, UK
1Department of Histopathology, St Bartholomews Hospital Westsmithfield, London EC1A 7BE
2Department of Histopathology, St Bartholomews Hospital, Royal Brompton National Heart and Lung Hospital Sidney Street, London SW3 6NP, UK

Pleural implant experiments using Sprague-Dawley rats have shown that those injected with the carcinogen 15,16-di-hydro-11-methylcyclopent [a]phenethren-17-one(11-methyl 17-ketone) intraperitoneally followed by silica fibres intrapleurally develop mesotheliomas. These tumours were histologically similar to those induced by crocidolite alone. The intraperitoneal injection of 11-methyl-17-ketone also induced leukaemia.


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