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© 1991 Oxford University Press

research-article

Inhibitory effects of micronutrients on pancreatic carcinogenesis in azaserine-treated rats

Marko J. Appel, Gerard Roverts and Ruud A. Woutersen 1

Department of Biological Toxicology, TNO Toxicology and Nutrition Institute PO Box 360, 3700 AJ Zeist, The Netherlands

1To whom reprint requests should be sent

A study was made on the effects of long-term dietary administration of ß-carotene, vitamin C, vitamin E and selenium, either alone or in combination, on azaserine-induced pancreatic carcinogenesis in rats. Male Wistar rats were given two i.p. injections of 30 mg azaserine per kg body weight at 19 and 26 days of age. The rats were allocated to eight groups of 40 animals each and were fed an AIN-76 diet rich in saturated fat (20% lard), either as such or after supplementation with ß-carotene, vitamin C, ß-carotene + vitamin C, vitamin E, selenium, vitamin E + selenium, or the combination of all micronutrients investigated. Fifteen months after the last treatment with azaserine the survivors were killed. The pancreata were examined for the number and size of advanced putative preneoplastic lesions and the number of neoplasms as well. Rats maintained on a diet high in either ß-carotene, vitamin C or selenium developed significantly less atypical acinar cell nodules, adenomas and carcinomas as compared to controls. The number of tumour-bearing animals was significantly lower in the groups fed the diet high in ß-carotene or selenium. In animals of the group given a diet high in all micronutrients investigated, both the number and incidence of pancreatic tumours was lower than in all other groups. It was concluded that selenium, ß-carotene and vitamin C, alone as well as in combination, have an inhibitory effect on pancreatic carcinogenesis induced in rats by azaserine.


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