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© 1991 Oxford University Press

research-article

Resistance of female Fischer-344 rats to the hepatonecrogenic and hepatocarcinogenic actions of a choline-devoid diet

R. Saito, L. Palomba, K.N. Rao and B. Lombardi 1

Department of Pathology, School of Medicine, University of Pittsburgh, and Pittsburgh Cancer Institute Pittsburgh, PA 15261, USA

1To whom correspondence should be addressed

A series of experiments was performed to investigate the response of female Fischer-344 rats to a choline-devoid (CD) diet. In contrast to findings previously made in male Fischer-344 rats, hepatocellular carcinomas did not develop in females chronically fed the diet. Their liver actually showed only minimal histopathological changes. For these reasons, the steatogenic and hepatonecrogenic actions of a CD diet were compared in male and female Fischer-344 rats. Young adult females were found to be largely resistant to both. The results were taken as further evidence of the primary and essential role played by an enhanced cell turnover in the pathogenesis of the carcinomas induced in male Fischer-344 rats by this non-chemical, nutritional model of hepatocarcinogenesis. A high incidence of preneoplastic and benign lesions developed in breast, pancreas or stomach of females chronically fed the CD diet. However, a similar specthim and high incidence of lesions was observed in control rats fed a choline-supplemented diet. These findings were attributed to an enhanced occurrence of spontaneous lesions, most likely due to the high fat content (15%) of the two diets used.


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 Toxicol PatholHome page
D. Nakae, Y. Mizumoto, N. Andoh, K. Tamura, K. Horiguchi, T. Endoh, E. Kobayashi, T. Tsujiuchi, A. Denda, B. Lombardi, et al.
Comparative Changes in the Liver of Female Fischer-344 Rats after Short-Term Feeding of a Semipurified or a Semisynthetic L-Amino Acid-Defined Choline-Deficient Diet
Toxicol Pathol, September 1, 1995; 23(5): 583 - 590.
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