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© 1991 Oxford University Press

research-article

The effect of Yoshida sarcoma cell transplantation to rats on the rate of acute-phase protein synthesis in the liver

Ljiljana Sevaljevic, Kiril Savovski 1 and Snezana Sekularac

Institute for Biological Research 29 novembra 142, Belgrade
1The Boris Kidric Institute for Nuclear Science Belgrade, Yugoslavia

The effect of transplantation of Yashida sarcoma cells into rats on the concentrations of both the acute-phase proteins (APPs) in the serum and their mRNAs in the liver has been investigated. In rats that responded to transplantation by forming solid tumors, the serum APP levels increased with tumors size. Some of the APP was found to be infiltrated in the area of the tumor cells. Concentrations of the APP mRNAs in the liver were enhanced to an extent comparable to that observed for the encoded proteins, indicating that hepatocytes were the major site of their synthesis. In rats in which no formation of solid tumors occurred, the serum APP concentrations expressed a tendency to decrease below the control values. An inverse relationship between the rates of APP synthesis and the capability of rats to prevent proliferation of transplanted ascites tumor cells in the solid tumor form was discussed.


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