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© 1992 Oxford University Press

research-article

Cell kinetic analysis of the mucosal epithelium and assay of ornithine decarboxylase activity during the process of 1-hydroxyanthraquinone-induced large bowel carcinogenesis in rats

Hideki Mori, Yoshio Mori, Takuji Tanaka, Naoki Yoshimi, Shigeyuki Sugie, Toshihiko Kawamori and Tomio Narisawa 1

Department of Pathology, Gifu University School of Medicine 40 Tsukasa-machi, Gifu 500
1Department of Surgery, Akita University School of Medicine 1-1-1 Hondo, Akita 010, Japan

Cell kinetics and activity of ornithine decarboxylase (ODC) were studied during the process of 1-hydroxyanthraquinone (1-HA)-induced intestinal carcinogenesis in rats. Starting at 6 weeks of age, a total of 37 male ACI/N rats were divided into two groups and treated as follows: group I (18 rats) received diet containing 1% 1-HA for 12 months; group II (19 rats) was given the basal diet alone. Sub-groups of 5/7 rats were sequentially killed at 4, 8 and 12 months for evaluation of the length, cell numbers and 5-bromo-2'-deoxyuridine (BrDU) labeling indices of large bowel crypts together with ODC activity. All kinetic and ODC data indicated increased DNA synthesis and proliferation at all time points. Morphological observation of the intestines also revealed melanosis, crypt abscesses and erosion, becoming more pronounced with length of exposure to the anthraquinone. The data thus suggest that cell proliferation in the crypts of the cecum or colon is important for 1-HA-induced intestinal carcinogenesis.


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Home page
 International Journal of ToxicologyHome page
B. E. Butterworth, O. B. Mathre, K. E. Ballinger, and O. Adalsteinsson
Contamination Is a Frequent Confounding Factor in Toxicology Studies with Anthraquinone and Related Compounds
International Journal of Toxicology, September 1, 2004; 23(5): 335 - 344.
[Abstract] [Full Text] [PDF]


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