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© 1992 Oxford University Press

research-article

Tissue distribution of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx) in two strains of male rats

Kjersti Tjøtta, Kristian Ingebrigtsen 1 and Tore Aune

Department of Food Hygiene, Norwegian College of Veterinary Medicine
1Department of Pharmacology and Toxicology, Norwegian College of Veterinary Medicine PO Box 8146, Dep., 0033 Oslo 1, Norway

Albino and hooded male rats were administered 14C-labded 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) by gavage. The tissue distribution was investigated by means of whole-body autoradiography and liquid scintillation counting. MeIQx was rapidly absorbed from the alimentary tract and distributed to several tissues. The major predilection sites were the liver and kidneys. The amount of radioactivity decreased dramatically within a few days. However, unextractable radioactive material was still detectable in these organs 6 days after the administration.


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