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© 1992 Oxford University Press

other

Aflatoxrn M1 in human breast milk from The Gambia, West Africa, quantified by combined monoclonal antibody immunoaffinity chromatography and HPLC

Audrey Zarba, Christopher P. Wild 1, Andrew J. Hall 1, Ruggero Montesano 1, Geoffrey J. Hudson 2 and John D. Groopman

Department of Environmental Health Sciences, The Johns Hopkins University School of Hygiene and Public Health 615 North Wolfe Street, Baltimore, MD 21205, USA
1International Agency for Research on Cancer 150 cours Albert Thomas, 69372 Cedex 08, Lyon. France
2Medical Research Council Dunn Nutrition Unit, Milton Road, Cambridge CB4 1XJ, UK

Maternal to child exposure of aflatoxin M1 in breast milk is an underevaluated risk factor from dietary exposure to aflatoxin B1. A molecular dosimetry study in The Gambia, West Africa, was initiated to explore the relationships between dietary intake of aflatoxins during a 1 week period and a number of aflatoxin biomarkers including aflatoxin metabolite excretion into breast milk. For the breast milk study, five lactating women were identified and milk samples were collected by hand expression once a day during days 3–7 for three women and during days 3–6 for the two other women. Afiatoxin M1 (AFM1) in human milk was measured in all five subjects by a preparative monoclonal antibody imniunoaffinity column/HPLC method. In three of the five women, aflatoxin G1 was found. Estimates of the percentage of aflatoxin in the diet excreted as AFM1 in milk ranged from 0.09 to 0.43%. Thus, these data indicate that a rapid methodology exists to assess the levels of AFM1 excretion in human milk and to use this approach as a biomarker for exposure of children to this carcinogen.


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