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© 1992 Oxford University Press

other

Involvement of prostaglandin E2 in ornithine decarboxylase induction by a tumor-promoting agent, 7-bromomethylbenz[a]anthracene, in mouse epidermis

Satoshi Yamamoto, Hong Jiang, Chino Otsuka and Ryuichi Kato

Department of Pharmacology, School of Medicine, Keio University 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan

A single topical application of 7-bromomethyl-benz[a]anthracene (BrMBA; 200 nmol) to mouse skin induced epidermal ornithlne decarboxylase (ODC) activity. A topical application of indomethacin (1.2 µmol), a cyclooxygenase inhibitor, 10 mm before BrMBA application markedly inhibited BrMBA-caused ODC induction. Concurrent application of prostaglandin E2 (PGE2; 0.1–1.5 µmol) reversed the inhibitory effect of indomethacin. Without indomethacin, PGE2 suppressed BrMBA-caused ODC induction. The results indicate that PGE2 has dual actions on the BrMBA-caused ODC induction, i.e. PGE2 plays an essential role in ODC induction caused by BrMBA, whereas exogenous PGE2 rather suppressed BrMBA-caused ODC induction.


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