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© 1992 Oxford University Press

research-article

Delayed reproductive death as a dominant phenotype in cell clones surviving X-irradiation

Wushou P. Chang 1 and John B. Little 2

1Present address: Institute of Public Health, National Yang Ming Medical University Taipei, Taiwan 11221

2To whom reprint requests should be sent

Residual damage manifested as reduced cloning efficiency was observed in many of the cloned progeny of Chinese hamster ovary (CHO) cells and human carcinoma SQ-20B cells surviving X-irradiation. This stable phenotype, which we have termed delayed reproductive death, persisted for >50 generations of cell replication post-irradiation. Clones showing this phenotype were aneuploid, and formed colonies with a high proportion of giant cells. By somatic cell hybridization of CHO clones, the delayed reproductive death phenotype was found to be a dominant trait; the cloning efficiency of hybrid clones was persistently depressed, as compared with that of control hybrid cells. These results suggest that delayed reproductive death represents a specific cellular response that may persist in some of the progeny of mammalian cells for long periods after X-irradiation.


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