Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Enzmann, H.
Right arrow Articles by Löser, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Enzmann, H.
Right arrow Articles by Löser, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1992 Oxford University Press

research-article

Foci of altered hepatocytes induced in embryonal turkey liver*

H. Enzmann, G. Kaliner 1, B. Watta-Gebert and E. Löser

Institute of Industrial Toxicology Bayer AG, Friedrich-Ebert-Strasse 217-333, D-5600 Wuppertal 1 , Germany
1Institute of Toxicology Pathology Bayer AG, Friedrich-Ebert-Strasse 217-333, D-5600 Wuppertal 1 , Germany

Fertilized turkey eggs were injected with N-nitrosomophollne (1–10 mg/egg) or urethane (0.1–10 mg/egg) prior to or during the first hours of incubation. Four days prior to hatching, the experiments were terminated and the livers of the embryos removed. The hepatocarcinogens induced focally arranged hepatocytes with morphological and metabolic changes that were similar to preneoplastic foci observed in rodent studies in vivo. Foci with enlarged cells and excessive storage of glycogen as well as basophilic foci with small cells, low in glycogen content and with frequent mitotic figures were found. The in ovo transformation of embryonal hepatocytes may be a promising rapid model of hepatocarcinogenesis.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Toxicol PatholHome page
H. Enzmann, C. Kuhlem, G. Kaliner, E. Loser, and P. Bannasch
Rapid Induction of Preneoplastic Liver Foci in Embryonal Turkey Liver by Diethylnitrosamine
Toxicol Pathol, September 1, 1995; 23(5): 560 - 569.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.