© 1992 Oxford University Press
research-article |
Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin
Laboratory for Cancer Rcscarch, Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers, The State University of New Jersey Piscataway, NJ 08855-0789
1Department of Food Science, Cook College, Rutgers, The State University of New Jersey New Brunswick, NJ 07103
2Department of Environmental and Community Medicine, UMDNJ-Robert Wood Johnson Medical School Piscataway, NJ 08854, USA
A green tea polyphenol fraction was evaluated for its ability to inhibit tumor initiation by polycydlic aromatic hydrocarbons and tumor promotion by a phorbol ester in the skin of CD-1 mice. Topical application of the green tea polyphenol fraction inhibited benzo[a]pyrene- and 7,12-dimethylbenz[a]- anthracene-induced tumor initiation as well as 12-O-tetra-decanoylpborbol-13-acetate (TPA)-induced tumor promotion. Topical application of the green tea polyphenol fraction also inhibited TPA-induced inflammation, ornithine decarboxylase activity, hyperplasia and hydrogen peroxide formation. Studies with Individual polyphenolic compounds in green tea indicated that topical application of (—)-epigallocatechin gallate, (—)-epigallocatechin and (—)-epicatechin gallate Inhibited TPA-induced inflanunation in mouse epidermis.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Rahman, R. A. Ansari, H. Rehman, S. Parvez, and S. Raisuddin Nordihydroguaiaretic Acid from Creosote Bush (Larrea tridentata) Mitigates 12-O-Tetradecanoylphorbol-13-Acetate-induced Inflammatory and Oxidative Stress Responses of Tumor Promotion Cascade in Mouse Skin Evid. Based Complement. Altern. Med., October 27, 2009; (2009) nep076v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Bode and Z. Dong Epigallocatechin 3-Gallate and Green Tea Catechins: United They Work, Divided They Fail Cancer Prevention Research, June 1, 2009; 2(6): 514 - 517. [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Meeran, M. Vaid, T. Punathil, and S. K. Katiyar Dietary grape seed proanthocyanidins inhibit 12-O-tetradecanoyl phorbol-13-acetate-caused skin tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated mouse skin, which is associated with the inhibition of inflammatory responses Carcinogenesis, March 1, 2009; 30(3): 520 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Zykova, Y. Zhang, F. Zhu, A. M. Bode, and Z. Dong The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols Carcinogenesis, February 1, 2005; 26(2): 331 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nagai, A. H. Conney, and B. T. Zhu STRONG INHIBITORY EFFECTS OF COMMON TEA CATECHINS AND BIOFLAVONOIDS ON THE O-METHYLATION OF CATECHOL ESTROGENS CATALYZED BY HUMAN LIVER CYTOSOLIC CATECHOL-O-METHYLTRANSFERASE Drug Metab. Dispos., May 1, 2004; 32(5): 497 - 504. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yamamoto, S. Hsu, J. Lewis, J. Wataha, D. Dickinson, B. Singh, W. B. Bollag, P. Lockwood, E. Ueta, T. Osaki, et al. Green Tea Polyphenol Causes Differential Oxidative Environments in Tumor versus Normal Epithelial Cells J. Pharmacol. Exp. Ther., October 1, 2003; 307(1): 230 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hsu, W. B. Bollag, J. Lewis, Q. Huang, B. Singh, M. Sharawy, T. Yamamoto, and G. Schuster Green Tea Polyphenols Induce Differentiation and Proliferation in Epidermal Keratinocytes J. Pharmacol. Exp. Ther., July 1, 2003; 306(1): 29 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Catterall, E. Copeland, M. N. Clifford, and C. Ioannides Effects of black tea theafulvins on aflatoxin B1 mutagenesis in the Ames test Mutagenesis, March 1, 2003; 18(2): 145 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nomura, A. Kaji, Z. He, W.-Y. Ma, K.-i. Miyamoto, C. S. Yang, and Z. Dong Inhibitory Mechanisms of Tea Polyphenols on the Ultraviolet B-activated Phosphatidylinositol 3-Kinase-dependent Pathway J. Biol. Chem., November 30, 2001; 276(49): 46624 - 46631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Katiyar, F. Afaq, A. Perez, and H. Mukhtar Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress Carcinogenesis, February 1, 2001; 22(2): 287 - 294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nomura, W.-y. Ma, N. Chen, A. M. Bode, and Z. Dong Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced NF-{kappa}B activation by tea polyphenols, (-)-epigallocatechin gallate and theaflavins Carcinogenesis, October 1, 2000; 21(10): 1885 - 1890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Katiyar, N. Ahmad, and H. Mukhtar Green Tea and Skin Arch Dermatol, August 1, 2000; 136(8): 989 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mimoto, K. Kiura, K. Matsuo, T. Yoshino, I. Takata, H. Ueoka, M. Kataoka, and M. Harada (-)-Epigallocatechin gallate can prevent cisplatin-induced lung tumorigenesis in A/J mice Carcinogenesis, May 1, 2000; 21(5): 915 - 919. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Yang, J. Y. Chung, G.-y. Yang, S. K. Chhabra, and M.-J. Lee Tea and Tea Polyphenols in Cancer Prevention J. Nutr., February 1, 2000; 130(2): 472 - 472. [Abstract] [Full Text]
|
|
|
|
|
|
V. E. Steele, G. J. Kelloff, D. Balentine, C. W. Boone, R. Mehta, D. Bagheri, C. C. Sigman, S. Zhu, and S. Sharma Comparative chemopreventive mechanisms of green tea, black tea and selected polyphenol extracts measured by in vitro bioassays Carcinogenesis, January 1, 2000; 21(1): 63 - 67. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhao, J. Wang, Y. Chen, and R. Agarwal Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation–promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent Carcinogenesis, September 1, 1999; 20(9): 1737 - 1745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Dhawan, S. Balasubramanian, A. J. Amonkar, and N. Singh Chemopreventive effect of 4'-demethyl epipodophyllotoxin on DMBA/TPA-induced mouse skin carcinogenesis Carcinogenesis, June 1, 1999; 20(6): 997 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-L. Lin and J.-K. Lin (-)-Epigallocatechin-3-gallate Blocks the Induction of Nitric Oxide Synthase by Down-Regulating Lipopolysaccharide-Induced Activity of Transcription Factor Nuclear Factor-kappa B Mol. Pharmacol., September 1, 1997; 52(3): 465 - 472. [Abstract] [Full Text]
|
|