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© 1993 Oxford University Press

research-article

Enhancing effect of concomitant L-ascorbic acid administration on BHA-induced forestomach carcinogenesis in rats

Masa-Aki Shibata 1, Masao Hirose, Masataka Kagawa, Pleumjit Boonyaphiphat 2 and Nobuyuki Ito

First Department of Pathology, Nagoya City University Medical School 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan
2Visiting scientist: Department of Pathology, Faculty of Medicine, Prince of Songkhla University Thailand

1To whom reprint requests should be sent

The effects of the synthetic antioxidant butylated hydroxyanisole (BHA) and naturally occurring antioxidants such as L-ascorbic acid (AsA; vitamin C), citric acid, benzoic acid or gallic acid in combination, on the development of rat forestomach epithelial lesions were investigated. A dietary level of 2.0% was selected for all antioxidants and the experimental period was 1 year. As compared with BHA alone, treatment with AsA in combination with BHA increased the severity of the hyperplasia in the mid-region, but not the prefundic region of the forestomach epithelium, as well as the multiplicity of forestomach tumors. Furthermore, incidences of squamous cell carcinomas (SCCs) in the forestomach were significantly elevated in this group, while papilloma development only showed a tendency to increase. In addition, SCC invasion into the muscle layer of the forestomach was observed only in the BHA + AsA group. Treatment with the other antioxidants did not affect BHA-induced forestomach lesion development. The present study demonstarted that AsA can clearly enhance BHA forestomach carcinogenesis.


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