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© 1993 Oxford University Press

other

Gap-junction protein gene suppresses tumorigenicity

Birgit Rose, Parmender P. Mehta and Werner R. Loewenstein

University of Miami School of Medicine, Department of Physiology and Biophysics Miami, FL 33136, USA

Prompted by the notion that the membrane channels in gap junctions conduct growth-regulating signals from cell to cell, we transferred the {alpha}1 gene for the channel protein (connexin43) of rat heart to tumorigenic mouse MCA-10 cells. Upon incorporation into the cell genome, this exogenous gene was expressed, resulting in functional channels and normal growth regulation: cell—cell communication, determined with a channel-permeant 400-dalton fluorescent tracer, was increased and tumorigenicity, determined in nude mice, was suppressed.


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