Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (30)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Timmins, G. S.
Right arrow Articles by Davies, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Timmins, G. S.
Right arrow Articles by Davies, M. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1993 Oxford University Press

research-article

Free radical formation in isolated murine keratinocytes treated with organic peroxides and its modulation by antioxidants

Graham S. Timmins and Michael J. Davies 1

Department of Chemistry, University of York York YO1 5DD, UK

1To whom correspondence should be addressed

Electron paramagnetic resonance spin-trapping has been used to study the production of free radicals from tert-butyl hydroperoxide, tert-butyl peroxybenzoate, cumene hydroperoxide and ethyl hydroperoxide in isolated murine keratinocytes. Free radical species could be trapped from keratinocytes treated with all peroxides, with radicals produced from both one-electron oxidative and reductive pathways. The hindered phenolic antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT), which are known to inhibit peroxide-induced tumour promotion in vivo, decreased the amount of radical adduct production at a concentration of 10 mM, with BHA being significantly more effective than BHT. That all the peroxides in this study produced free radicals in keratinocytes, and that BHA and BHT decreased the amounts of radicals trapped, suggests that free radical production by organic peroxide compounds is involved in their in vivo tumour-promoting activity.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 CarcinogenesisHome page
A.R. Murray, E.R. Kisin, C Kommineni, V Vallyathan, V Castranova, and A.A. Shvedova
Pro/antioxidant status and AP-1 transcription factor in murine skin following topical exposure to cumene hydroperoxide
Carcinogenesis, July 1, 2007; 28(7): 1582 - 1588.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. Hanausek, Z. Walaszek, A. Viaje, M. LaBate, E. Spears, D. Farrell, R. Henrich, A. Tveit, E. F. Walborg Jr, and T. J. Slaga
Exposure of mouse skin to organic peroxides: subchronic effects related to carcinogenic potential
Carcinogenesis, March 1, 2004; 25(3): 431 - 437.
[Abstract] [Full Text] [PDF]

Home page
 International Journal of ToxicologyHome page
Final Report on the Safety Assessment of BHT
International Journal of Toxicology, October 1, 2002; 21(2_suppl): 19 - 94.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.