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© 1993 Oxford University Press

other

A novel CYP1A1 gene polymorphism in African-Americans

Frances Crofts, Greg N. Cosma, Diane Currie, Emanuela Taioli, Paolo Toniolo and Seymour J. Garte 1

Nelson Institute of Environmental Medicine, New York University Medical Center New York, NY 10016, USA

1To whom correspondence should be addressed

A new Mspl RFLP in the CYP1A1 gene has been found in genomic DNA from African-Americans. The polymorphism results from a single A-T to G-C transition in the 3' noncoding region {small tilde}300 bp upstream from the polyadenylation site. This mutation leads to cleavage of the normal 2.3 kb Mspl restriction fragment into 1.3 and 1.0 kb fragments. The heterozygous mutation has been seen in 8 of 47 African-Americans, but was not detected in 191 Caucasians or 30 Asians. No linkage was observed with either of the two previously described polymorphisms in this gene.


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