© 1993 Oxford University Press
Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer
S. Zhong,
A.H. Wyllie 1,
D. Barnes 2,
C.R. Wolf 3 and
N.K. Spurr 4
Biomedical Research Centre, ICRF Molecular Pharmacology Unit, Level 5 Ninewells Hospital Dundee, DD1 9SY
1The Cancer Research Campaign Laboratories, Department of Pathology, University Edinburgh, George Square, Edinburgh EH8 9XD
2ICRF Clinical Oncology Unit, Guy's Hospital London SE1 9RT
4ICRF Clare Hall Laboratories Blanche Lane, South Mimms, Potters Bar, Herts EN6 3LD, UK
3To whom correspondence should be addressed
Mammalian cytosolic glutathione S-transferases (GSTs; EC 2.5.1.18) form a supergene family consisting of four distinct families, named alpha, mu, pi and theta. In humans one member of the mu class gene family (GSTM1) has been shown to be polymorphic and is only expressed in 55–60% of individuals. Previous studies have shown a possible link with the null phenotype and susceptibility to cancer, in particular to lung cancer. In this study we genotyped individuals with breast, bladder and colorectal cancer. A total of 490 individuals with cancer were studied, and consisted of 97 bladder, 197 breast and 196 colorectal cancers. No significant differences were observed in the frequency of nulled individuals in bladder or breast cancer patients when compared with a control population of 225 individuals. However, a significant excess of nulled individuals were seen in colorectal cancer: 56.1% compared with the control group value of 41.8%. This was shown to be highly significant depending on the site of the tumours and >70% of individuals with a tumour in the proximal colon were GSTM1 nulled. This is an 
2-fold increase in colon cancer risk in these individuals.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
|
|
 
T. Horiuchi, M. Washio, C. Kiyohara, H. Tsukamoto, Y. Tada, T. Asami, S. Ide, G. Kobashi, H. Takahashi, and the Kyushu Sapporo SLE Study Group
Combination of TNF-RII, CYP1A1 and GSTM1 polymorphisms and the risk of Japanese SLE: findings from the KYSS study
Rheumatology,
September 1, 2009;
48(9):
1045 - 1049.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Qiu, S. Leng, Z. Wang, Y. Dai, Y. Zheng, and Z. Wang
Path Analysis of Biomarkers of Exposure and Early Biological Effects among Coke-Oven Workers Exposed to Polycyclic Aromatic Hydrocarbons
Cancer Epidemiol. Biomarkers Prev.,
June 1, 2007;
16(6):
1193 - 1199.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Chen, Y. Bai, J. Yuan, W. Chen, J. Sun, H. Wang, H. Liang, L. Guo, X. Yang, H. Tan, et al.
Association of Polymorphisms in AhR, CYP1A1, GSTM1, and GSTT1 Genes with Levels of DNA Damage in Peripheral Blood Lymphocytes among Coke-Oven Workers.
Cancer Epidemiol. Biomarkers Prev.,
September 1, 2006;
15(9):
1703 - 1707.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L A Criswell, K G Saag, T R Mikuls, J R Cerhan, L A Merlino, R F Lum, K A Pfeiffer, B Woehl, and M F Seldin
Smoking interacts with genetic risk factors in the development of rheumatoid arthritis among older Caucasian women
Ann Rheum Dis,
September 1, 2006;
65(9):
1163 - 1167.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S.F. Doney, S. Lee, G. P. Leese, A. D. Morris, and C. N.A. Palmer
Increased Cardiovascular Morbidity and Mortality in Type 2 Diabetes Is Associated With the Glutathione S Transferase Theta-Null Genotype: A Go-DARTS Study
Circulation,
June 7, 2005;
111(22):
2927 - 2934.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E.M.J. van der Logt, S.M. Bergevoet, H.M.J. Roelofs, Z. van Hooijdonk, R.H.M. te Morsche, T. Wobbes, J.B. de Kok, F.M. Nagengast, and W.H.M. Peters
Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk
Carcinogenesis,
December 1, 2004;
25(12):
2407 - 2415.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Leng, Y. Dai, Y. Niu, Z. Pan, X. Li, J. Cheng, F. He, and Y. Zheng
Effects of Genetic Polymorphisms of Metabolic Enzymes on Cytokinesis-Block Micronucleus in Peripheral Blood Lymphocyte among Coke-Oven Workers
Cancer Epidemiol. Biomarkers Prev.,
October 1, 2004;
13(10):
1631 - 1639.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. D. Vogl, E. Taioli, C. Maugard, W. Zheng, L. F. Ribeiro Pinto, C. Ambrosone, F. F. Parl, V. Nedelcheva-Kristensen, T. R. Rebbeck, P. Brennan, et al.
Glutathione S-transferases M1, T1, and P1 and Breast Cancer: A Pooled Analysis
Cancer Epidemiol. Biomarkers Prev.,
September 1, 2004;
13(9):
1473 - 1479.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. M. Egan, Q. Cai, X.-O. Shu, F. Jin, T.-L. Zhu, Q. Dai, Y.-T. Gao, and W. Zheng
Genetic Polymorphisms in GSTM1, GSTP1, and GSTT1 and the Risk for Breast Cancer: Results from the Shanghai Breast Cancer Study and Meta-Analysis
Cancer Epidemiol. Biomarkers Prev.,
February 1, 2004;
13(2):
197 - 204.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Barnette, R. Scholl, M. Blandford, L. Ballard, A. Tsodikov, J. Magee, S. Williams, M. Robertson, F. Ali-Osman, R. Lemons, et al.
High-Throughput Detection of Glutathione S-Transferase Polymorphic Alleles in a Pediatric Cancer Population
Cancer Epidemiol. Biomarkers Prev.,
February 1, 2004;
13(2):
304 - 313.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Rollinson, A. P. Levene, F. K. Mensah, P. L. Roddam, J. M. Allan, T. C. Diss, E. Roman, A. Jack, K. MacLennan, M. F. Dixon, et al.
Gastric marginal zone lymphoma is associated with polymorphisms in genes involved in inflammatory response and antioxidative capacity
Blood,
August 1, 2003;
102(3):
1007 - 1011.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. de Jong, I. M. Nolte, G. J. te Meerman, W. T. A. van der Graaf, E. G. E. de Vries, R. H. Sijmons, R. M. W. Hofstra, and J. H. Kleibeuker
Low-penetrance Genes and Their Involvement in Colorectal Cancer Susceptibility
Cancer Epidemiol. Biomarkers Prev.,
November 1, 2002;
11(11):
1332 - 1352.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Sachse, G. Smith, M. J.V. Wilkie, J. H. Barrett, R. Waxman, F. Sullivan, D. Forman, D. T. Bishop, and C.R. Wolf
A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer
Carcinogenesis,
November 1, 2002;
23(11):
1839 - 1850.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. S. Engel, E. Taioli, R. Pfeiffer, M. Garcia-Closas, P. M. Marcus, Q. Lan, P. Boffetta, P. Vineis, H. Autrup, D. A. Bell, et al.
Pooled Analysis and Meta-analysis of Glutathione S-Transferase M1 and Bladder Cancer: A HuGE Review
Am. J. Epidemiol.,
July 15, 2002;
156(2):
95 - 109.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M M de Jong, I M Nolte, G J te Meerman, W T A van der Graaf, J C Oosterwijk, J H Kleibeuker, M Schaapveld, and E G E de Vries
Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility
J. Med. Genet.,
April 1, 2002;
39(4):
225 - 242.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-S. Chen, L. S. Chang, H.-W. Chen, and Y.-H. Wei
Polymorphisms of glutathione S-transferase M1 and male infertility in Taiwanese patients with varicocele
Hum. Reprod.,
March 1, 2002;
17(3):
718 - 725.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. F. Firozi, M. L. Bondy, A. A. Sahin, P. Chang, F. Lukmanji, E. S. Singletary, M. M. Hassan, and D. Li
Aromatic DNA adducts and polymorphisms of CYP1A1, NAT2, and GSTM1 in breast cancer
Carcinogenesis,
February 1, 2002;
23(2):
301 - 306.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Liu, D. P. Miller, W. Zhou, S. W. Thurston, R. Fan, L.-L. Xu, T. J. Lynch, J. C. Wain, L. Su, and D. C. Christiani
Differential Association of the Codon 72 p53 and GSTM1 Polymorphisms on Histological Subtype of Non-Small Cell Lung Carcinoma
Cancer Res.,
December 1, 2001;
61(24):
8718 - 8722.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R.M. Hadfield, S. Manek, D.E. Weeks, H.J. Mardon, D.H. Barlow, and S.H. Kennedy
Linkage and association studies of the relationship between endometriosis and genes encoding the detoxification enzymes GSTM1, GSTT1 and CYP1A1
Mol. Hum. Reprod.,
November 1, 2001;
7(11):
1073 - 1078.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Loktionov, M. A. Watson, M. Gunter, W. S.L. Stebbings, C. T.M. Speakman, and S. A. Bingham
Glutathione-S-transferase gene polymorphisms in colorectal cancer patients: interaction between GSTM1 and GSTM3 allele variants as a risk-modulating factor
Carcinogenesis,
July 1, 2001;
22(7):
1053 - 1060.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Mitrunen, N. Jourenkova, V. Kataja, M. Eskelinen, V.-M. Kosma, S. Benhamou, H. Vainio, M. Uusitupa, and A. Hirvonen
Glutathione S-Transferase M1, M3, P1, and T1 Genetic Polymorphisms and Susceptibility to Breast Cancer
Cancer Epidemiol. Biomarkers Prev.,
March 1, 2001;
10(3):
229 - 236.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. IZZOTTI, C. CARTIGLIA, J. LEWTAS, and S. DE FLORA
Increased DNA alterations in atherosclerotic lesions of individuals lacking the GSTM1 genotype
FASEB J,
March 1, 2001;
15(3):
752 - 757.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Rundle, D. Tang, J. Zhou, S. Cho, and F. Perera
The Association between Glutathione S-Transferase M1 Genotype and Polycyclic Aromatic Hydrocarbon-DNA Adducts in Breast Tissue
Cancer Epidemiol. Biomarkers Prev.,
October 1, 2000;
9(10):
1079 - 1085.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S Semple, F Dick, A Osborne, J W Cherrie, A Soutar, A Seaton, and N Haites
Impairment of colour vision in workers exposed to organic solvents
Occup. Environ. Med.,
September 1, 2000;
57(9):
582 - 587.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
L.E. Johns and R.S. Houlston
Glutathione S-transferase {micro}1 (GSTM1) status and bladder cancer risk: a meta-analysis
Mutagenesis,
September 1, 2000;
15(5):
399 - 404.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Inoue, C. Kiyohara, T. Marugame, S. Shinomiya, E. Tsuji, K. Handa, H. Hayabuchi, K. Onuma, H. Hamada, H. Koga, et al.
Cigarette Smoking, CYP1A1 MspI and GSTM1 Genotypes, and Colorectal Adenomas
Cancer Res.,
July 1, 2000;
60(14):
3749 - 3752.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
P. A. Thompson and C. Ambrosone
Chapter 7: Molecular Epidemiology of Genetic Polymorphisms in Estrogen Metabolizing Enzymes in Human Breast Cancer
J Natl Cancer Inst Monographs,
July 1, 2000;
2000(27):
125 - 134.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Millikan, G. Pittman, C.-K. Tse, D. A. Savitz, B. Newman, and D. Bell
Glutathione S-Transferases M1, T1, and P1 and Breast Cancer
Cancer Epidemiol. Biomarkers Prev.,
June 1, 2000;
9(6):
567 - 573.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. A. Lallas, S. K. McClain, M. S. Shahin, and R. E. Buller
The Glutathione S-Transferase M1 Genotype in Ovarian Cancer
Cancer Epidemiol. Biomarkers Prev.,
June 1, 2000;
9(6):
587 - 590.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. Rollinson, P. Roddam, E. Kane, E. Roman, R. Cartwright, A. Jack, and G. J. Morgan
Polymorphic variation within the glutathione S-transferase genes and risk of adult acute leukaemia
Carcinogenesis,
January 1, 2000;
21(1):
43 - 47.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Garcia-Closas, K. T. Kelsey, S. E. Hankinson, D. Spiegelman, K. Springer, W. C. Willett, F. E. Speizer, and D. J. Hunter
Glutathione S-Transferase Mu and Theta Polymorphisms and Breast Cancer Susceptibility
J Natl Cancer Inst,
November 17, 1999;
91(22):
1960 - 1964.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. S. Coughlin and M. Piper
Genetic Polymorphisms and Risk of Breast Cancer
Cancer Epidemiol. Biomarkers Prev.,
November 1, 1999;
8(11):
1023 - 1032.
[Full Text]
|
|
|
|
|
|
|
A. M. Dunning, C. S. Healey, P. D. P. Pharoah, M. D. Teare, B. A. J. Ponder, and D. F. Easton
A Systematic Review Of Genetic Polymorphisms and Breast Cancer Risk
Cancer Epidemiol. Biomarkers Prev.,
October 1, 1999;
8(10):
843 - 854.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M.C. Lemos, F.J. Cabrita, H.A. Silva, M. Vivan, F. Placido, and F.J. Regateiro
Genetic polymorphism of CYP2D6, GSTM1 and NAT2 and susceptibility to haematological neoplasias
Carcinogenesis,
July 1, 1999;
20(7):
1225 - 1229.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. J. Nair, J. Nair, B. Mathew, and H. Bartsch
Glutathione S-transferase M1 and T1 null genotypes as risk factors for oral leukoplakia in ethnic Indian betel quid/tobacco chewers
Carcinogenesis,
May 1, 1999;
20(5):
743 - 748.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Welfare, A. M. Adeokun, M. F. Bassendine, and A. K. Daly
Polymorphisms in GSTP1, GSTM1, and GSTT1 and Susceptibility to Colorectal Cancer1
Cancer Epidemiol. Biomarkers Prev.,
April 1, 1999;
8(4):
289 - 292.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Chen and W. Nirunsuksiri
Decreased expression of glutathione S-transferase M1 in HPV16-transfected human cervical keratinocytes in culture
Carcinogenesis,
April 1, 1999;
20(4):
699 - 703.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Krajinovic, D. Labuda, C. Richer, S. Karimi, and D. Sinnett
Susceptibility to Childhood Acute Lymphoblastic Leukemia: Influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 Genetic Polymorphisms
Blood,
March 1, 1999;
93(5):
1496 - 1501.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. M. M. van Lieshout, H. M. J. Roelofs, S. Dekker, C. J. J. Mulder, T. Wobbes, J. B. M. J. Jansen, and W. H. M. Peters
Polymorphic Expression of the Glutathione Polymorphic Expression of the Glutathione S-Transferase P1 Gene and Its Susceptibility to Barrett's Esophagus and Esophageal Carcinoma
Cancer Res.,
February 1, 1999;
59(3):
586 - 589.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. B. Ambrosone, B. F. Coles, J. L. Freudenheim, and P. G. Shields
Glutathione-S-transferase (GSTM1) Genetic Polymorphisms Do Not Affect Human Breast Cancer Risk, Regardless of Dietary Antioxidants
J. Nutr.,
February 1, 1999;
129(2):
565 - 565.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. R. Fields, C. S. Morrow, A. J. Doss, K. Sundberg, B. Jernström, and A. J. Townsend
Overexpression of Stably Transfected Human Glutathione S-Transferase P1-1 Protects against DNA Damage by Benzo[a]pyrene Diol-Epoxide in Human T47D Cells
Mol. Pharmacol.,
August 1, 1998;
54(2):
298 - 304.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. A. McLellan, M. Oscarson, A.-K. Alexandrie, J. Seidegård, D. A. P. Evans, A. Rannug, and M. Ingelman-Sundberg
Characterization of a Human Glutathione S-Transferase µ Cluster Containing a Duplicated GSTM1 Gene that Causes Ultrarapid Enzyme Activity
Mol. Pharmacol.,
December 1, 1997;
52(6):
958 - 965.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A L Hubbard, D J Harrison, C Moyes, A H Wyllie, C Cunningham, E Mannion, and C A D Smith
N-acetyltransferase 2 genotype in colorectal cancer and selective gene retention in cancers with chromosome 8p deletions
Gut,
August 1, 1997;
41(2):
229 - 234.
[Abstract]
[Full Text]
[PDF]
|
|
|
