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© 1993 Oxford University Press

research-article

Induction of lung and liver tumors by flouranthene in a preweanling CD-1 mouse bioassay

Jia-Sheng Wang 1 and William F. Busby, Jr 2

Division of Toxicology and Center for Environmental Health Sciences, Massachusetts Institute of Technology Cambridge, MA 02139, USA

2To whom correspondence should be addressed at: Room 20C-032, Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge MA 02139, USA

Fluoranthene (FA), a major enviromental pollutant, induced lung and liver tumors 6–9 months after intraperitoneal injection of 0.7, 1.75 and 3.5 mg FA into preweanling CD-1 mice. There was a dose-dependent increase in lung tumors with a maximum tumor incidence of nearly 45% and a maximum tumor multiplicity of 0.6–0.7 lung tumors/mouse. No significant difference was noted in lung tumors in the 6 and 9 month bioassays, although fewer tumors were consistently noted in mice treated with the two lowest doses of FA. Indices of lung tumor incidence (ED50) and multiplicity (TM1.0) were similar for the two bioassays and ranged from 18.9–19.5 and 26.2–27.2 µmol respectively. Male mice had up to two times more lung tumors than females but these results were not statistically significant. Liver tumors (nodular hyperplasia) appeared only in FA-treated males but no dose-response relationship was evident. However, liver tumors were observed in only 0–10% of the male mice in the 6 month treatment groups, but in 20–60% of the males in the 9 month groups. Because the CD-1 preweanling mouse responded to the weak lung tumorigen FA, it is a viable, limited-term bioassay for measuring tumorigenicity of PAH and combustion emissions.


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