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© 1995 Oxford University Press

other

The DNA binding activity of the liver transaction factors LFB1 (HNF1) AND HNF4 varies coordinately in rat hepatocellular carcinoma

Holger Stumpf, Sabine Senkel, Hartmut M. Rabes 1 and Gerhart U. Ryffel 2

Institu für Zellbiologie (Tumorforschung), Universitätsklinikum Essen Hufelandstrasse 55, D-45122 Essen
1Pathologisches Institut der Universität Thalkirchner Strasse 36, D-80337 Müchen, Germany

2To whom correspondence sould be addressed

As renal cell carcinomas are characterized by the disappearance of the transcription factor LFB1, which is know to be primarily involved in gene regulation in the liver, we have measured the presence of LGB1 in rat hepatocellular carcinomas induced by diethylnitrosamine. The level of LFB1 binding activity in adenoid-cystic as well as trabecular tumours shows some variation and may either be lowe or higher than in the non-tumorous tissue. The amount of LFB1 binding activity correlates with the binding activity HNF4, a transcription factor reported to stimulate LGB1 expression. As the levels of LFB1 and HNF4 binding activity differ extensively in various hepatocellular carcinomas, it is unlikely that these transcription factors play a general role in hepatocarcino-genesis. This is in contrast to renal carcinogenesis where a dramatic loss of LFB1 is a consistent feature.


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