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© 1995 Oxford University Press

research-article

N-Acetylation and N-formylation of carcinogenic arylamines and related compounds in dogs

Fumikazu Okumura 1, Osamu Ueda 2, Shigeyuki Kitainura and Kiyoshi Tatsuml 3

Institute of Pharmaceutical Science, Hiroshima University School of Medicine 1–2–3 Kasumi, Minami-ku, Hiroshima 734, Japan

3To whom correspondence should be addressed

When sulfanilamide, p-amlnobenzoic acid, 4-amino- biphenyl, 2-aminofluorene or 1-aminopyrene was given orally to dogs, the corresponding N-acetyl and N-formyl derivatives were isolated from urine or feces. These metabolites were identified unequivocally by comparison with an authentic sample by UV and mass spectrometry and their behavior in TLC and HPLC. Dog intestinal flora and several bacterial strains exhibited both N-acetylatlng and N-formylating activities, in varying degrees, toward all of the arylamines tested. The metabolites formed by the intestinal bacteria were also isolated and identified unequivocally. The results suggest that the intestinal microflora plays an important role in the formation of N-acyl derivatives from arylamines in dogs.


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