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© 1995 Oxford University Press

research-article

Normal human cells at confluence get heat resistance by efficient accumulation of HSP72 in nucleus

Masami Watanabe, Keiji Suzuki, Seiji Kodama and Tsutomu Sugahara 1

Division of Radiation Biology, Department of Health Sciences, Faculty of Pharmaceutical Sciences, Nagasaki University 1-14 Bunkyo-machi, Nagasaki 852
1Health Research Foundation Kyoto 606, Japan

We Investigated the heat-sensitivity of normal human cells and cells derived from human cancers (cancer cells) heated at 43°C under different culture conditions. Primary human cells which keep in contact with each other show heat resistance, but cancer cells do not. This does not correlate with the total cellular amount of heat shock protein 72, but rather with accumulation of the protein In the nucleus after heating.


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Home page
 CarcinogenesisHome page
N. Hamada, S. Kodama, K. Suzuki, and M. Watanabe
Gap junctional intercellular communication and cellular response to heat stress
Carcinogenesis, November 1, 2003; 24(11): 1723 - 1728.
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