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© 1995 Oxford University Press

research-article

Molecular analysis of mutations induced by 2-chloroacetaldehyde, the ultimate carcinogenic form of vinyl chloride, in human cells using shuttle vectors

Tomonari Matsuda, Takashi Yagi 1, Masanobu Kawanishi, Saburo Matsui and Hiraku Takebe 1 2

Center for Environmental Quality Control, Kyoto University 1-2 Yumihama, Otsu, Shiga 520
1Department of Radiation Genetics, Faculty of Medicine. Kyoto University Yoshida-konoe-cho, Sakyo-ku, Kyoto 606-01, Japan

2To whom correspondence should be addressed

Vinyl chloride (VC) is a carcinogen associated with human and animal cancers. The ultimate carcinogenic form of VC, 2-chloroacetaldehyde (CAA), has been suspected to be mutagenic and we confinned the mutagenicity of CAA using a modified shuttle vector plasmid. Base sequence analyses of 109 mutant plasmids with mutations in the supF gene, which were treated with CAA and propagated in the cultured human cells, revealed that more than half of the single base substitutions were G:C to A:T transitions with eight hotspots. The majority of the mutations involving G:C base pairs were in 5'-AAGG-3' or 5'-CCTT-3' sequences suggesting that these sequences are the main targets of mutagenesis caused by CAA.


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