© 1995 Oxford University Press
research-article |
Enhancement of esophageal carcinogenesis in male F344 rats by dietary phenylhexyl isothiocyanate
Department of Preventive Medicine, Laboratory of Cancer Chemoprevention and Etiology, The Ohio State University, Arthur G.James Cancer Hospital and Research Institute Room 1148, 300 West 10th Avenue, Columbus, OH 43210–1240, USA
1Department of Pathology, Medical College of Ohio 3000 Arlington Avenue, Toledo, OH 43614, USA
2Division of Chemical Carcinogenesis, American Health Foundation Valhalla, NY 10595, USA
3To whom correspondence should be sent
The purpose of this study was to evaluate the potential effects of dietary 6-phenylhexyl isothiocyanate (PHITC) on N-nitrosomethylbenzylamine (NMBA)-induced esophageal carcinogenesis in rats. Groups of 15 male F344 rats received weekly s.c. injections of NMBA in 20% dimethylsulfoxide or the vehicle alone for 15 consecutive weeks. Two weeks prior to initiation of carcinogen or vehicle injections rats were provided with modified AIN-76A diet or modified AIN-76A diet containing PHITC at levels of 0.4, 1.0 or 2.5 µmol/g diet. Experimental controls consisted of groups that received only the vehicle (vehicle controls), NMBA (carcinogen controls) or PHITC at the high dose level of 2.5 µmol/g diet. No esophageal tumors or preneoplastic lesions were detected in rats that received the vehicle or PHITC alone. In contrast, all rats treated with NMBA alone or PHITC + NMBA exhibited esophageal tumors and preneoplastic esophageal lesions. In groups that received PHITC + NMBA tumor multiplicity was increased by 21–69% when compared with rats treated with NMBA alone, indicating that PHITC enhanced esophageal tumorigenesis in this model system. These results, in conjunction with our previous work, demonstrate that arylalkyl isothiocyanates may inhibit or enhance esophageal tumorigenesis in the NMBA-treated rat. The ability of isothiocyanates to inhibit or enhance experimental tumorigenesis may depend on alkyl chain length of the isothiocyanate, the animal species examined and the specific carcinogen employed.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G. D. Stoner and A. Gupta Etiology and chemoprevention of esophageal squamous cell carcinoma Carcinogenesis, November 1, 2001; 22(11): 1737 - 1746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F.-L. Chung, C.C. Conaway, C.V. Rao, and B. S. Reddy Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate Carcinogenesis, December 1, 2000; 21(12): 2287 - 2291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Hecht Chemoprevention of Cancer by Isothiocyanates, Modifiers of Carcinogen Metabolism J. Nutr., March 1, 1999; 129(3): 768 - 768. [Abstract] [Full Text]
|
|