Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (39)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Dunnick, J. K.
Right arrow Articles by Barrett, J.C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dunnick, J. K.
Right arrow Articles by Barrett, J.C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1995 Oxford University Press

article-commentary

Chemically induced mammary gland cancer in the National Toxicology Program's carcinogenesis bioassay

June K. Dunnick, Michael R. Elwell, James Huff and J.Carl Barrett

National Institute of Environmental Health Sciences Research Triangle Park, NC 275 14, USA

Incidences of breast cancer change in populations as people migrate from one area of the world to another, suggesting that environmental factors contribute to this disease. There is a continuing effort to identify these environmental factors and the role that exposures to specific chemicals play in this disease. Results from experimental studies show that chemicals identified to cause mammary gland cancer in rodents are frequently mutagenic chemicals, suggesting that genetic damage is an important mechanism for the induction of this cancer. Prevalent classes of chemicals that were identified to cause mammary gland cancer in rodents in studies by the National Toxicology Program include halogenated hydrocarbons, aromatic amino/nitro compounds and epoxide-forming chemicals. Results from these experimental studies will help to elucidate mechanisms and possible causes of breast cancer in humans.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Toxicol SciHome page
J. Huff
Carcinogenicity of Bisphenol A Revisited
Toxicol. Sci., December 1, 2002; 70(2): 281 - 283.
[Full Text] [PDF]

Home page
 Toxicol PatholHome page
P. E. Blackshear
Genetically Engineered Rodent Models of Mammary Gland Carcinogenesis: An Overview
Toxicol Pathol, January 1, 2001; 29(1): 105 - 116.
[Abstract] [PDF]

Home page
 Toxicol PatholHome page
J. K. Dunnick, J. E. Heath, D. R. Farnell, J. D. Prejean, J. K. Haseman, and M. R. Elwell
Carcinogenic Activity of the Flame Retardant, 2,2-Bis(bromomethyl)-1,3-Propanediol in Rodents, and Comparison with the Carcinogenicity of Other NTP Brominated Chemicals
Toxicol Pathol, November 1, 1997; 25(6): 541 - 548.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.