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© 1995 Oxford University Press

research-article

Inhibition of tumor promotion in benzo[a]pyrene-initiated CD-1 mouse skin by crocetin

Chau-Jong Wang 2, Miao-Jane Lee, Ming-Cheng Chang and Jen-Kun Lin 1

Institute of Biochemistry, Chung Shan Medical and Dental College Taichung
1Institute of Biochemistry, College of Medicine, National Taiwan University Taipei, Taiwan, Republic of China

2To whom correspondence should be addressed

The effects of topical application of crocetin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced promotion of skin tumors, hyperplasia, hydrogen peroxide, ornithine decarboxylase (ODC) and inflammation were evaluated in female CD-1 mice. Topical application of crocetin (0.2 or 1.0 µmol) with TPA (15 nmol) twice weekly for 20 weeks to mice previously initiated with benzo[{alpha}]pyrene (B[{alpha}]P) inhibited the number of TPA-induced tumors per mouse by 69 and 81% respectively. Pre-application of the same amount of crocetin also afforded significant protection against TPA-induced hyperplasia in the ear skin. Topical application of crocetin inhibited tumor promoter-caused induction of epidermal ODC activity by TPA (5 nmol). The topical application of crocetin (0.2 or 1.0 µmol) inhibited TPA-induced edema of mouse ears by 76 and 87% respectively. Pretreatment of mouse skin with various amounts of crocetin caused inhibition of hydrogen peroxide and myeloperoxidase production by TPA. These results indicate that crocetin possesses potential as a cancer chemopreventive agent against tumor promotion.


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 JPEN J Parenter Enteral NutrHome page
R. Yang, X. Tan, A. M. Thomas, J. Shen, N. Qureshi, D. C. Morrison, and C. W. Van Way III
Crocetin Inhibits mRNA Expression for Tumor Necrosis Factor-{alpha}, Interleukin-1{beta}, and Inducible Nitric Oxide Synthase in Hemorrhagic Shock
JPEN J Parenter Enteral Nutr, July 1, 2006; 30(4): 297 - 301.
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