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© 1995 Oxford University Press

research-article

Urine of tobaccolareca nut chewers causes genomic damage in Chinese hamster ovary cells

Amit H. Trivedi, Shambhu K. Roy, Rashmi K. Patel, Siddharth G. Adhvaryu and Damodar B. Balar

Cell Biology Division, Department of Cancer Biology, The Gujarat Cancer and Research Institute NCH Campus, Ahmedabad 380 016, India

The chromosome-damaging effects of urine concentrates (UCs) from tobacco plus areca nut (T/AN) chewers (a highly popular habit and a major risk factor for oral cancer in India) were evaluated on Chinese hamster ovary (CHO) cells employing two cytogenetic end-points, namely chromosome aberration (CA) and sister chromatid exchange (SCE) frequencies. Urine creatinine levels were comparable between controls and T/AN chewers. CA and SCE frequencies in CHO cells were found to be elevated significantly (P < 0.001) following treatment with UCs prepared from T/AN chewers (UC-T/AN chewers) as well as with UCs of non-chewer controls (UC-control subjects). Moreover, elevation of these two parameters by UC-T/AN chewers was significantly higher in comparison to that of UC-controls. The results of the present study indicated that besides the oral cavity, which is a target organ for T/AN chewers, mutagen/scarcinogens in tobacco and areca nut might be playing a causative role in cancer of the urinary bladder as well.


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