Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (53)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Liu, M.-L.
Right arrow Articles by Michalopoulos, G. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liu, M.-L.
Right arrow Articles by Michalopoulos, G. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1995 Oxford University Press

research-article

Hepatocyte growth factor inhibits cell proliferation in vivo of rat hepatocellular carcinomas induced by diethylnitrosamine

Meng-Lun Liu 1, Wend M. Mars and George K. Michalopoulos 2

Department of Pathology, University of Pittsburgh School of Medicine Pittsburgh, PA 15261, USA

2To whom all correspondence and reprint requests should be addressed

In addition to its mitogenic, motogenic and morphogenic functions on various cell types, hepatocyte growth factor (HGF) also suppresses mitosis in several cancer cell lines, including carcinomas and sarcomas. Here we report that HGF is also mito-inhibitory in rat liver tumors induced by diethylnitrosamine. By using a double labeling technique employing [3H]thymidine and 5-bromo-2'-deoxyuridine to determine cell proliferation before and after HGF infusion, we determined that continuous infusion of 20 µg total HGF inhibited tumor cell proliferation by 50%. The labeling in non-tumor areas showed the reverse result in that the labeling was higher in HGF-treated rats than control rats. These results indicate that HGF has different effects on growth of normal and tumorous hepatocytes in vivo. These findings may be of relevance in understanding the role of HGF in hepatocarcinogenesis and provide added modalities for controlling growth of hepatocellular carcinomas.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Genomics ProteomicsHome page
F. A. MALIK, A. J. SANDERS, M. A. KAYANI, and W. G. JIANG
Effect of Expressional Alteration of KAI1 on Breast Cancer Cell Growth, Adhesion, Migration and Invasion
Cancer Genomics Proteomics, July 1, 2009; 6(4): 205 - 213.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Takami, P. Kaposi-Novak, K. Uchida, L. E. Gomez-Quiroz, E. A. Conner, V. M. Factor, and S. S. Thorgeirsson
Loss of Hepatocyte Growth Factor/c-Met Signaling Pathway Accelerates Early Stages of N-nitrosodiethylamine Induced Hepatocarcinogenesis
Cancer Res., October 15, 2007; 67(20): 9844 - 9851.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Han, Y.-i. Tsukada, E. Hara, N. Kitamura, and T. Tanaka
Hepatocyte Growth Factor Induces Redistribution of p21CIP1 and p27KIP1 through ERK-dependent p16INK4a Up-regulation, Leading to Cell Cycle Arrest at G1 in HepG2 Hepatoma Cells
J. Biol. Chem., September 9, 2005; 280(36): 31548 - 31556.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. Kiss, R. Ortiz-Aguayo, R. Sharp, G. Merlino, S. S. Thorgeirsson, F. J. Gonzalez, and J. M. Peters
Evidence that reduction of hepatocyte growth factor (HGF) is not required for peroxisome proliferator-induced hepatocyte proliferation
Carcinogenesis, June 1, 2001; 22(6): 975 - 979.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
L. M. Brennan, E. M. Boncavage-Hennessey, M. J. Wolfe, M. W. Toussaint, W. E. Dennis, A. B. Rosencrance, and H. S. Gardner JR
An In Vivo Method for Using 5-Bromo-2'-deoxyuridine (BrdU) as a Marker of Chemically-Induced Hepatocellular Proliferation in the Japanese Medaka (Oryzias latipes)
Toxicol Pathol, April 1, 2001; 29(3): 387 - 397.
[Abstract] [PDF]

Home page
 EndocrinologyHome page
L. R. Qadan, C. M. Perez-Stable, R. H. Schwall, K. L. Burnstein, R. C. Ostenson, G. A. Howard, and B. A. Roos
Hepatocyte Growth Factor and Vitamin D Cooperatively Inhibit Androgen-Unresponsive Prostate Cancer Cell Lines
Endocrinology, July 1, 2000; 141(7): 2567 - 2573.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Arakaki, T. Kajihara, R. Arakaki, T. Ohnishi, J. A. Kazi, H. Nakashima, and Y. Daikuhara
Involvement of Oxidative Stress in Tumor Cytotoxic Activity of Hepatocyte Growth Factor/Scatter Factor
J. Biol. Chem., May 7, 1999; 274(19): 13541 - 13546.
[Abstract] [Full Text] [PDF]

Home page
 Cell Growth Differ.Home page
D. Ronen, R. T. Altstock, M. Firon, L. Mittelman, T. Sobe, J. H. Resau, G. F. Vande Woude, and I. Tsarfaty
Met-HGF/SF Mediates Growth Arrest and Differentiation in T47D Breast Cancer Cells
Cell Growth Differ., February 1, 1999; 10(2): 131 - 140.
[Abstract] [Full Text]

Home page
 J. Histochem. Cytochem.Home page
J. Y. Ljubimova, L. M. Petrovic, S. E. Wilson, S. A. Geller, and A. A. Demetriou
Expression of HGF, Its Receptor c-met, c-myc, and Albumin in Cirrhotic and Neoplastic Human Liver Tissue
J. Histochem. Cytochem., January 1, 1997; 45(1): 79 - 88.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-i. Tsukada, K. Miyazawa, and N. Kitamura
High Intensity ERK Signal Mediates Hepatocyte Growth Factor-induced Proliferation Inhibition of the Human Hepatocellular Carcinoma Cell Line HepG2
J. Biol. Chem., October 26, 2001; 276(44): 40968 - 40976.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.