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© 1995 Oxford University Press

research-article

Up-regulation of resistance-related proteins in human lung tumors with poor vascularization

Reet Koomägi, Jürgen Mattern 1 and Manfred Volm 1 2

Department of Radiology and Oncology, Tartu University Tartu, Estonia
1German Cancer Research Center Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

2To whom correspondence should be addressed

Microvessel density was investigated by immunostaining endothelial cells for factor VIII antigen in 84 non-small cell lung carcinomas and compared with the expression of several resistance-related proteins. Glutathione S-transferase-{pi}, thymidylate synthase, metallothionein and, with limitations, P-glycoprotein were overexpressed in tumors with poor vascularization.


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