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© 1996 Oxford University Press

research-article

Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics, strongly promotes tumorigenesis initiated by 4-nitroquinoline 1-oxide in the lungs of mice

Kenzo Yamanaka 1, Kaori Ohtsubo, Akira Hasegawa, Hiroyuki Hayashi 2, Hiroshi Ohji 2, Masayoshi Kanisawa 2 and Shoji Okada 1 2

Department of Biochemical Toxicology, Nihon University College of Pharmacy 7-7-1 Narashinodai, Funabashi-shi, Chiba 274
2Department of Pathology, Yokoham City University School of Medicine 3-9 Fuku-ura. Kanazawa-ku, Yokohama 236
3Department of Radiobiochemistry, University of Shizuoda School of Pharmaceuticfal Sciences 52-1 Yada. Shizuoka-shi, Shizuoka 422, Japan

1To whom requests for reprins should be addressed

The effect of dimethylarsenics on the pulmonary tumorigenesis initiated by 4-nitroquinoline 1-(4NQO) in mice was examined. The exposure of mice to dimethylarsinic acid (DMAA), a major metabolite of inorganic arsenics in mammals, resulted in not only promotion but also progression of the tumorigenic process in the lungs of mice administered 4NQO. Furthermore, dimethylarsenice influenced the differentiation process in lung tumorigenesis by 4NQO. These results may pave the way for the elucidation of lung carcinogenesis caused by arsenics.


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