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SHORT COMMUNICATION: Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers
Department of Surgery, School of Postgraduate Medicine, North Staffordshire Hospital, Keele University
1Department of Respiratory Medicine, North Staffordshire Hospital UK
2Department of Oral and Maxillofacial Surgery, North Staffordshire Hospital UK
3National Institutes of Environmental Health Sciences PO Box 12233, Research Triangle Park, NC 27709, USA
4Department of Mathematics, Keele University Keele, Staffordshire, UK
5Clinical Biochemistry Research Laboratory, School of Postgraduate Medicine, North Staffordshire Hospital, Staffordshire, Stoke-on-Trent UK
6To whom correspondence should be addressed
Allelism in glutathione S-transferase GSTM1 and GSTT1 has been suggested as a risk factor in various cancers. Accordingly, we describe a group of case-control studies carried out to identify associations between GSTT1 genotypes and susceptibility to lung, oral, gastric and colorectal cancers. The frequencies of the putatively high risk GSTT1 null genotype were not increased in the lung, oral or gastric cancer cases compared with controls but the frequency of this genotype was significantly increased (P = 0.0011, odds ratio = 1.88) in the colorectal cancer cases. No significant interactions between the GSTT1 and GSTM1 null genotypes were identified in the cancer groups studied. Indeed, no significant associations between GSTM1 genotypes and susceptibility were identified though further evidence was obtained that the protective effect of GSTM1*A and GSTM1*B is not equal. The data complement studies showing that GSTT1 null is associated with an increased susceptibility to total ulcerative colitis and suggests that this enzyme is important in the detoxification of unidentified xenobiotics in the large intestine.
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