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© 1996 Oxford University Press

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SHORT COMMUNICATION: Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear vitamin D receptor

Annette Clairmont, Dirk Tessmann, Anke Stock, Swantje Nicolai, Wilhelm Stahi and Helmut Sies 1

Institut für Physiologische Chemie I, Hienrich-Heine-Universität Postfach 101007, D-40001 Düsseldorf, Germany

1To whom correspondence should be addressed

The physiologically active metabolite of vitamin D, 1{alpha}, 25-dihydroxyvitamin D3 (calcitriol), induces gap junctional intercellular communication in human skin fibroblasts 161BR at a concentration of 10–7. In human skin fibroblasts, FIB5, devoid of a functional nuclear vitamin D receptor (VDR), there is no effect on gap junctional intercellular communication. Parallel to the increase in cell-cell communication, we observed a VDR-dependent increase in connexin 43 protein and connexin 43 mRNA levels. These results suggest that 1{alpha}, 25-dihydroxyvitamin D3 affects gap junctional intercellular communication at the level of transcription or of mRNA stability via the nuclear VDR.


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